Unintended Consequences: ADE

Modern Medicine routinely encounters Unintended Consequences.

Unexpected Benefit
A positive unexpected benefit (also referred to as luck, serendipity or a windfall).

Unexpected Drawback
An unexpected detriment occurring in addition to the desired effect of the policy (e.g., while irrigation schemes provide people with water for agriculture, they can increase waterborne diseases that have devastating health effects, such as schistosomiasis).

Perverse Result
A perverse effect contrary to what was originally intended (when an intended solution makes a problem worse).

In medicine, most drugs have unintended consequences (‘side effects’) …

Wikipedia – Unintended Consequences

Wikipedia mentions the Unexpected Medical Benefits of Aspirin and Viagra.

In medicine, most drugs have unintended consequences (‘side effects’) associated with their use. However, some are beneficial.

For instance, aspirin, a pain reliever, is also an anticoagulant that can help prevent heart attacks and reduce the severity and damage from thrombotic strokes.

Famously, the drug Viagra was developed to lower blood pressure, with its use for treating erectile dysfunction being discovered as a side effect in clinical trials.

Wikipedia – Unintended Consequences

But the Unexpected Medical Benefits of Hydroxychloroquine and Ivermectin are most definitely out of bounds.

Hydroxychloroquine is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth, often in the form of hydroxychloroquine sulfate.

Hydroxychloroquine was approved for medical use in the United States in 1955.

Hydroxychloroquine is not effective for preventing coronavirus disease 2019 (COVID-19) infection. There is no strong scientific evidence to support the use of hydroxychloroquine as a COVID-19 treatment. While its use is not approved by the FDA for COVID-19 treatment, from April to June 2020, there was an emergency use authorization for its use in the United States, and it has been used off label for potential treatment of the disease. On 24 April 2020, citing the risk of “serious heart rhythm problems”, the FDA posted a caution against using the drug for COVID-19 “outside of the hospital setting or a clinical trial”. On 15 June, the FDA revoked its emergency use authorization, stating that it was “no longer reasonable to believe” that the drug was effective against COVID-19 or that its benefits outweighed “known and potential risks”.

Wikipedia – Hydroxychloroquine

What the CDC forgot to mention was that this “one small study” found that no patients had “PCR-positive samples” after being treated with a combination of hydroxychloroquine and azithromycin for five days.

In fact, it’s difficult to understand the Information for Clinicians issued by the CDC because chloroquine+coronavirus research dates back to [at least] 2005.

Malaga Bay – Treatment Guidelines

Ivermectin is a medication used to treat many types of parasite infestations. In humans, this includes head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis.

Ivermectin was discovered in 1975 and came into medical use in 1981.
It is on the World Health Organization’s List of Essential Medicines.
Ivermectin is FDA-approved as an antiparasitic agent.

As of January 2021, the U.S. National Institutes of Health COVID-19 Treatment Guidelines state that the evidence for ivermectin is too limited to allow for a recommendation for or against its use.

Ivermectin is not approved by the FDA for anti-viral use.

Wikipedia – Ivermectin

And so, it is with great pride as well as significant optimism, that I am here to report that our group, led by Professor Paul E. Marik, has developed a highly effective protocol for preventing and early treatment of COVID-19. In the last 3-4 months, emerging publications provide conclusive data on the profound efficacy of the anti-parasite, anti-viral drug, anti-inflammatory agent called ivermectin in all stages of the disease. Our protocol was created only recently, after we identified these data. Nearly all studies are demonstrating the therapeutic potency and safety of ivermectin in preventing transmission and progression of illness in nearly all who take the drug.

Testimony of Pierre Kory, MD
Homeland Security Committee Meeting: Focus on Early Treatment of COVID-19
December 8, 2020


And the Unexpected Medical Drawbacks of Thalidomide aren’t mentioned by Wikipedia in the context of Unintended Consequences.

Thalidomide was first marketed in 1957 in West Germany, where it was available over the counter. When first released, thalidomide was promoted for anxiety, trouble sleeping, “tension”, and morning sickness.

While it was initially thought to be safe in pregnancy, concerns regarding birth defects arose in 1961 and the medication was removed from the market in Europe that year.

The total number of embryos affected by use during pregnancy is estimated at 10,000, of which about 40% died around the time of birth.

Those who survived had limb, eye, urinary tract, and heart problems.

Wikipedia – Thalidomide

Wikipedia classifies the Duplessis Orphans as an Perverse Result.

Beginning in the 1940s and continuing into the 1960s, the Canadian federal government gave the Catholic Church in Quebec $2.25 per day per psychiatric patient for their cost of care, but only $0.75 a day per orphan.

The perverse result is that the orphan children were diagnosed as mentally ill so the church could receive the larger amount of money.

This psychiatric misdiagnosis affected up to 20,000 people, and the children are known as the Duplessis Orphans.

Wikipedia – Unintended Consequences

But fails to mention the Perverse Medical Result called ADE.

Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into host cells, followed by its replication.

This phenomenon might lead to both increased virus infectivity and virulence.

ADE can occur during the development of a primary or secondary viral infection, as well as after vaccination with a subsequent virus challenge.

It has been observed mainly with positive-strand RNA viruses.

Among them are Flaviviruses such as Dengue virus, Yellow fever virus, Zika virus, Coronaviruses, including alpha- and betacoronaviruses, Orthomyxoviruses such as influenza, Retroviruses such as HIV, and Orthopneumoviruses such as RSV.

Coronavirus vaccines
VADE might hamper vaccine development, as a vaccine may trigger the production of antibodies which, via ADE and other mechanisms, worsen the disease the vaccine is designed to protect against.

This was a concern during late clinical stages of vaccine development against COVID-19.

Wikipedia – Antibody-Dependent Enhancement

Since the 1960s, tests of vaccine candidates for diseases such as dengue, respiratory syncytial virus (RSV), and severe acute respiratory syndrome (SARS) have shown a paradoxical phenomenon: Some animals or people who received the vaccine and were later exposed to the virus developed more severe disease than those who had not been vaccinated.

Some researchers argue that although ADE has received the most attention to date, it is less likely than the other immune enhancement pathways to cause a dysregulated response to COVID-19, given what is known about the epidemiology of the virus and its behavior in the human body.

“There is the potential for ADE, but the bigger problem is probably Th2 immunopathology,” says Ralph Baric, an epidemiologist and expert in coronaviruses—named for the crown-shaped spike they use to enter human cells—at the University of North Carolina at Chapel Hill.

In previous studies of SARS, aged mice were found to have particularly high risks of life-threatening Th2 immunopathology.

Baric expresses his concern about what that might mean for use of a COVID-19 vaccine in elderly people. “Of course, the elderly are our most vulnerable population,” he adds.

“You really have to test a vaccine carefully,” says Marc Lipsitch, an epidemiologist at the Harvard Chan School of Public Health in Boston, MA, “and not just roll it out because people are clamoring for it with an epidemic underway.”

Avoiding pitfalls in the pursuit of a COVID-19 vaccine
Lynne Peeples
PNAS April 14, 2020 117 (15) 8218-8221; first published March 30, 2020;


Dr Lee Merrit Interview
Peter Humphrey – 16 Jan 2021

Transcript: https://malagabay.files.wordpress.com/2021/02/dr-lee-merrit-interview-transcript.pdf

Bitchute: https://www.bitchute.com/video/eJGDoepOVHRk/

Overall, it’s impossible to guarantee mRNA “vaccines” wont [ever] trigger ADE when the vaccinated individual is subsequently exposed [say during a flu season] to:

a) The targeted “virus” [or one of it’s relations]
b) A mutated form of the “virus” [or one of it’s relations]
c) A malevolently manipulated form of the “virus” [or one of it’s relations].

This is especially true with the experimental mRNA “vaccines” receiving “emergency use authorization” because they haven’t been subjected to long term human trials.

An RNA vaccine or mRNA (messenger RNA) vaccine is a type of vaccine that uses a copy of a natural chemical called messenger RNA (mRNA) to produce an immune response.

In RNA therapeutics, mRNA vaccines have attracted considerable interest as COVID-19 vaccines.

By December 2020, there were two novel mRNA vaccines for COVID-19 that had completed the required eight-week period post-final human trials and were awaiting emergency use authorization (EUA): the Moderna COVID-19 vaccine (mRNA-1273) and the Pfizer–BioNTech COVID-19 vaccine (BNT162b2).

Wikipedia – RNA vaccine

Wikipedia – COVID-19 Vaccine

Development of new vaccine technology has been plagued with problems in the past.

The current RNA based SARS-CoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing.

In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients.

The enclosed finding as well as additional potential risks leads the author to believe that regulatory approval of the RNA based vaccines for SARS-CoV-2 was premature and that the vaccine may cause much more harm than benefit.

COVID-19 RNA Based Vaccines and the Risk of Prion Disease
J Bart Classen – Microbiol Infect Dis. 2021; 5(1): 1-3


UK Column News – 12th February 2021: https://youtu.be/wC4awKLVHG4

As always:

Review the evidence and draw your own conclusions.


501 Deaths + 10,748 Other Injuries Reported Following COVID Vaccine,
Latest CDC Data Show

As of Jan. 29, about 35 million people in the U.S. had received one or both doses of a COVID vaccine.

According to the latest data, 453 of the 501 reported deaths were in the U.S.

Fifty-three percent of those who died were male, 43% were female, the remaining death reports did not include the gender of the deceased.

The average age of those who died was 77, the youngest reported death was of a 23-year-old.

The Pfizer vaccine was taken by 59% of those who died, while the Moderna vaccine was taken by 41%.

The latest data also included 690 reports of anaphylactic reactions to either the Pfizer or Moderna vaccines. Of those, the Pfizer vaccine accounted for 76% of the reactions, and the Moderna vaccine for 24%.

The Defender – Children’s Health Defense – 5 Feb 2021

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

It typically causes more than one of the following: an itchy rash, throat or tongue swelling, shortness of breath, vomiting, lightheadedness, low blood pressure. These symptoms typically come on over minutes to hours.

Common causes include insect bites and stings, foods, and medications.

Other causes include latex exposure and exercise.

Additionally, cases may occur without an obvious reason.

The mechanism involves the release of mediators from certain types of white blood cells triggered by either immunologic or non-immunologic mechanisms.

Diagnosis is based on the presenting symptoms and signs after exposure to a potential allergen.

Wikipedia – Anaphylaxis

CDC recently updated estimated infection fatality rates for COVID.
Here are the updated survival rates by age group:

 0-19 : 99.997%
20-49 : 99.980%
50-69 : 99.500%
   70+: 94.600%

CDC Data Shows High Virus Survival Rate: 99%-Plus for Ages 69 and Younger, 94.6% for Older – Breitbart.com – Edwin Mora – 25 Sep 2020

The endemic ineptitude of government is illustrated by the Cobra Effect.

The cobra effect occurs when incentives designed to solve a problem end up rewarding people for making it worse. The term is used to illustrate how incorrect stimulation in economics and politics can cause unintended consequences.

The British government was concerned about the number of venomous cobras in Delhi.

The government therefore offered a bounty for every dead cobra. Initially, this was a successful strategy; large numbers of snakes were killed for the reward.

Eventually, however, enterprising people began to breed cobras for the income.

When the government became aware of this, the reward program was scrapped.

When cobra breeders set their now-worthless snakes free, the wild cobra population further increased.

Wikipedia – Cobra Effect

The British Raj was the rule by the British Crown on the Indian subcontinent from 1858 to 1947.

Wikipedia – British Raj

Whether the inept British copied the inept French [or vice versa] isn’t clear.

A similar incident occurred in Hanoi, Vietnam, under French colonial rule.

In 1902, the colonial government created a bounty program that paid a reward for each rat killed. To collect the bounty, people would need to provide the severed tail of a rat.

Colonial officials, however, began noticing rats in Hanoi with no tails.

The Vietnamese rat catchers would capture rats, sever their tails, and then release them back into the sewers so that they could procreate and produce more rats, thereby increasing the rat catchers’ revenue.

Wikipedia – Cobra Effect

Either way:

The COBRA crisis management facility in London provides a constant reminder of the endemic ineptitude of governments that are predisposed to screw the pooch.

WhatDoTheyKnow – COBR

The Cabinet Office Briefing Rooms (COBR) are meeting rooms in the Cabinet Office in London. These rooms are used for committees which co-ordinate the actions of government bodies in response to national or regional crisis, or during overseas events with major implications for the UK.

It is popularly referred to as COBRA.

Wikipedia – Cabinet Office Briefing Rooms

screw the pooch

To make a very serious, grievous, or irreversible mistake;

Farlex Dictionary of Idioms. © 2015 Farlex, Inc, all rights reserved.

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14 Responses to Unintended Consequences: ADE

  1. Patrick Donnelly says:

    We must all lose our bodies. Some will lose them earlier than expected. Those who do not, may learn … or not.
    This is the fiorst of the pandemics.

    I see no reason why there will not be more. At least, they will be declared!

  2. malagabay says:

    A curious correlation from Gibraltar.

    Gibraltar started its vaccine rollout on 10 January 2021.

    Why Is There A Correlation Between The Vaccine Rollout And Increased COVID–19 Mortality? – UK Column – Iain Davis – 2nd February 2021

    Double check.

    Vaccinations started on 10 January with front line hospital staff first in line.

    Wikipedia – COVID-19 pandemic in Gibraltar

  3. malagabay says:

    In the United Kingdom it’s Amateur Hour because they are evidently incapable of adding together the deaths from England, Northern Ireland, Scotland, and Wales on a daily basis.

    Independent observers are left to decide for themselves whether the United Kingdom “immunisation campaign” is more cull than cure [or vice versa].

    On 8 December, the immunisation campaign commenced, with 90 year-old Margaret Keenan becoming the first individual to receive the Pfizer–BioNTech COVID-19 vaccine, the first administration of a COVID-19 vaccine outside of a clinical trial.

    This milestone was dubbed “V-day” by some media outlets, an allusion that combined the initial of “vaccine” with a reference to wartime victory celebrations.

    She received her second dose on 29 December, and then had a 5 day wait for optimum protection.

    Wikipedia – COVID-19 pandemic in the United Kingdom

  4. malagabay says:

    First care home residents in England to get Covid-19 vaccines in early Christmas present

    Care home residents and staff had been prioritised for a vaccine, but logistical hurdles slowed the roll-out until now

    Care home residents and staff in England are set to get their first Covid-19 vaccines this week, including on Christmas Eve, in an early present for a sector that has been devastated by the virus.

    GPs will begin administering Pfizer/BioNTech vaccinations in care homes all over the country over the next few days, after being asked if they could start the programme over the weekend.

    The Telegraph – Jennifer Rigby – 23 December 2020

  5. malagabay says:

    One of the mysteries of the COVID-19 Daily Death Data from the United Kingdom is the 20th January 2021 peak.

    Wikipedia – COVID-19 pandemic in the United Kingdom

    One possible solution for this mystery is the ending of the care home vaccination “bonus” of £30 on 17 January 2021.

    GPs offered £30 bonus per care home COVID jab in bid to speed up rollout
    Primary care networks (PCNs) will be paid an extra £30 per dose of COVID-19 vaccine administered to patients in care homes by the end of 17 January as the NHS looks to speed up rollout of the vaccination programme in England.

    GPonline – Nick Bostock – 13 Jan 2021


    The basic State Pension (alongside the Graduated Retirement Benefit, the State Earnings-Related Pension Scheme, and the State Second Pension) is payable to men born before 6 April 1951, and to women born before 6 April 1953. The maximum amount payable is £137.60 a week (12 April 2021 – 10 April 2022).

    The new State Pension is payable to men born on or after 6 April 1951, and to women born on or after 6 April 1953. The maximum amount payable is £179.60 a week (12 April 2021 – 10 April 2022).

    Wikipedia – State Pension (United Kingdom)

  6. Patrick Donnelly says:

    Ar you familiar with the phrase “they died form complications following the procedure”?
    This means the body responded to the insult of surgery by clotting.

    Serrapeptase is safe, has no LD50, and dissolves clots. A real life saver, but as it is not a poison, cannot be prescribed by ‘doctors’!

  7. johnm33 says:

    I’ve noticed that when I ‘fail’ to have the textbook response to a medication the Docs get shirty and tend to double down with something stronger I’ve seen this escalation in others before their demise through “complications”.
    As for pensions it’s really a terrible thought but with huge numbers of boomers retiring and expected to outlive their predecessors, nothing saved, an economy ravaged by offshoring production and with Russia and China refusing to be economically shafted something had to be done to reduce liabilities. Just fucking wow, or is there a better explanation?

    • malagabay says:

      Just fucking wow, or is there a better explanation?

      It’s worth noting:

      1) The lockdowns have been used to separate the “essential” from the “chaff”.
      2) The long term effects of the mRNA “vaccines” are unknown.

      Time will tell.

  8. malagabay says:

    The UK Government’s reporting system for COVID vaccine adverse reactions from the Medicines and Healthcare products Regulatory Agency released their latest report today, March 4, 2021.

    The report covers data collected from December 9, 2020, through February 21, 2021, for the two experimental COVID vaccines currently in use in the U.K. from Pfizer and AstraZeneca.

    They report a total of 460 deaths and 243,612 injuries.

    Health Impact News – Brian Shilhavy – 4 March 2021

    + + + +

    The overall safety experience with both vaccines is so far as expected from the clinical trials

    Data from the UK Public Health agencies show that at least 17,723,840 people have received their first vaccination in the UK by week ending 21 February 2021, with 624,325 second doses administered.

    Coronavirus Vaccine – Summary of Yellow Card reporting

    Coronavirus (COVID-19) vaccine adverse reactions

    + + + +


    + + + +

  9. malagabay says:

    7 European Nations Halt AstraZeneca Jabs On Reports Of “Serious” Blood Clots

    Update (0820ET): More countries have followed Denmark by suspending approval of the AstraZeneca-Oxford COVID vaccine. Norway, Denmark, Estonia, Lithuania, Luxembourg, Latvia, and Italy have now opted to halt use of the vaccine, creating more problems for Europe’s sluggish vaccine rollout.

    The halts follow incidents involving blood clots in patients who recently received the vaccine.

    Two incidents were reported in Austria, although Vienna is allowing the vaccine to continue to be used, at least for now.

    Serious cases of blood clots have been reported in Denmark and other countries as well.

    Zero Hedge – Tyler Durden – 11 March 2021

  10. malagabay says:

    Norwegians run a greater risk of dying from being inoculated with AstraZeneca’s vaccine than from COVID-19, the National Institute of Public Health (FHI) concluded in its analysis, recommending the vaccine, previously linked to serious complications in the form of rare blood clotting and haemorrhage amid low platelet counts.

    The FHI stressed that continuing to inoculate will by contrast expose younger women to an “unreasonably high risk”, given the current relatively levels of infection in Norway.

    Norway: Risk of Dying From AstraZeneca Higher Than of COVID-19
    Sputnik News – Igor Kuznetsov – 23 April 2021

  11. malagabay says:

    The Indian Bar Association has taken legal action against the World Health Organization’s (WHO) Chief Scientist Dr. Soumya Swaminathan for allegedly spreading disinformation on the use of ivermectin to treat COVID-19.

    In a May 10 Twitter post that was deleted after Swaminathan received the notice, she wrote,

    “Safety and efficacy are important when using any drug for a new indication. WHO recommends against the use of ivermectin for COVID-19 except within clinical trials.”

    Swaminathan made the post soon after Goa’s health minister announced that every Goa resident 18 and older would be given ivermectin as prevention regardless of their COVID-19 status, as part of the Indian state’s effort to stop the transmission of the virus.

    Uttar Pradesh, one of the most populous states in India with more than 200 million people, has been handing out free medical kits containing seven days’ worth of medication, one of which is ivermectin, for COVID-19 positive patients under home isolation.

    The Epoch Times – Meiling Lee – 8 June 2021

  12. malagabay says:

    India began its vaccination programme on 16 January 2021
    and by April was administering 3–4 million doses a day.

    Source: https://en.wikipedia.org/wiki/COVID-19_India

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